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Garrison-Morton-Norman History of Medicine
Historical Bibliography Updated: June 17, 2026

Vascular reactions of the skin to injury. II. The liberation of a histamine-like substance in injured skin; the underlying cause of factitious urticaria and of wheals produced by burning; and observations upon the nervous control of certain skin reactions.

LEWIS, Sir Thomas (1881 – 1945)
LEWIS, Sir Thomas (1881 – 1945) Wikipedia
GRANT, Ronald Thomson (1892 – 1989) rcplondon.ac.uk

Publication Details

Heart, 11, 209-65. 1924 CE.

Lewis postulated that a histamine-like substance (“H-substance”) was responsible for the anaphylaxis symptom-complex. See also The blood-vessels of the human skin and their responses, 1927 (No. 797).

Thematic Classifications

ALLERGYDERMATOLOGY
Catalog MetadataReference Information
Entry Number#2602
Permanent Linkhttps://staging.historyofmedicine.com/entry/3024
Author Bio LinkWikipedia ↗
External URLvascular-reactions-of-the-skin-to-injury-ii-the-liberation-of-a-histaminelike-substance-in-injured-skin-the-underlying-cause-of-factitious-urticaria-and-of-wheals-produced-by-burning-and-observations-upon-the-nervous-control-of-certain-skin-reactions