Transplantation of isolated pancreatic islets into the portal vein of diabetic rats.

Lacy and colleagues showed that transplanation of murine pancreatic islet tissue into the portal vein of diabetic rats of the same inbred strain normalized the sugar levels and urine output of the rats that received the islet transplants. This was the proof of concept paper for islet transplantation in humans.

(Thanks to Juan Weiss for this reference and its interpretation.)