Defining criteria for autoimmune diseases (Witebsky's postulates revisited).

In 1993 Rose and Bona revised Witebsky's postulates "based on direct evidence from transfer of pathogenic antibody or pathogenic T-cells, indirect evidence based on reproduction of the autoimmune disease in experimental animals and circumstantial evidence from clinical clues.:^[5]

• Auto-antibodies detectable in all cases of disease.
• Experimentally reproducible by immunization with antigen.
• Experimental disease must show immunopathological lesions that parallel those in the natural disease.
• Transferable by serum or lymphoid cells." (Wikipedia article on Ernst Witebsky, accessed 8-2021).