The significance of Streptococcus hemolyticus in scarlet fever and the preparation of a specific anti-scarlatinal serum by immunization of the horse to Streptococcus hemolyticus-scarlatinae.

Dochez and Sherman immunized a horse by repeated injections of scarlet fever toxin. A serum obtained from the horse blanched a scarlet fever rash and, when injected subcutaneously, caused marked amelioration of the early symptoms. They also confirmed the relation of streptococci to scarlet fever.