Peptidotriazoles on Solid Phase: [1,2,3]-Triazoles by Regiospecific Copper(I)-Catalyzed 1,3-Dipolar Cycloadditions of Terminal Alkynes to Azides.

In 2022 Morten Meldal shared the Nobel Prize in Chemistry with Carolyn Bertozzi and Barry Sharpless for the discovery of click chemistry. Simultaneously, but independently of Sharpless, the authors discovered that copper substantially catalyzes
the cycloaddition reaction between azides and terminal alkynes. The efficiency of this reaction, combined with robustness and ease of operation, quickly made this the "go to" for transformations this sort. This reaction became the very epitome of click chemistry.

Order of authorship in the original publication: Tornoe, Christensen, Meldal.

(Thanks to Juan Weiss for this reference and its interpretation.)