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Historical Bibliography Updated: June 16, 2026

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless.

Publication Details

Cell, 93, 805-814. 1998 CE.

In 1998 Rosbach, Hall and colleagues discovered the cycle gene, clock gene, and cryptochrome photoreceptor in Drosophila through the use of forward genetics, by first identifying the phenotype of a mutant and then determining the genetics behind the mutation. 
Order of authorship in the original publication: Rutila, Suri, Le, So, Rosbash, Hall. Digital text from cell.com at this link.

See also: Stanewsky, R.; Kaneko, M.; Emery, P.; Beretta, B.; Wager-Smith, K.; Kay, S.A.; Rosash, M.; Hall, J. C.,  "The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila," Cell, 95, 1998, 681-682.

Thematic Classifications

Catalog MetadataReference Information
Entry Number#14264
Permanent Linkhttps://staging.historyofmedicine.com/entry/16585
Author Bio LinkWikipedia ↗
External URLcycle-is-a-second-bhlhpas-clock-protein-essential-for-circadian-rhythmicity-and-transcription-of-drosophila-period-and-timeless