Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.

Gilman and colleagues showed that G proteins are in the cell membrane and are stimulated once a ligand (adrenaline) binds the adrenergic receptor. This system can then activate adenyl cyclase to form cyclic AMP. Digital facsimile from PubMedCentral at this link.

Order of authorship in the original publication: Ross, Howlett, Ferguson, Gilman.

(Thanks to Juan Weiss for this reference and its interpretation.)