Recherches sur l’arachnitis chronique, la gastrite et la gastro-entérite chroniques, et la goutte: Considerées comme causes de l'aliénation mentale. Thèse No. 247.

First description of  general paresis, or paralytic dementia, general paralysis of the insane, or "maladie de Bayle". This is considered the first demonstation of an organic cause for a "psychiatric" disorder; it was influential in drawing the attention of psychiatrists to other disorders of the nervous system as possible causes of other "mental" disorders. Commercial issue: Paris, Didot le Jeune, 1822. Partial English translation in Arch. Neurol. Psychiat. (Chicago), 1934, 32, 808-829. Digital facsimile from the University of Calgary at this link.