Mémoire sur le sang quand il est fluide, pendant qu’il se coagule et lorsqu’il est coagulé.

The first attempt to isolate and describe fibrinogen, the blood protein essential for clotting. “Prosper-Sylvain Denis, in his Mémoire sur le sang (1859), was the first to recognize that plasma contained a clottable substance, not defined as a liquid fibrin, but different from fibrin, and he attempted to purify and characterize this protein. He independently proposed the name fibrinogène” (Rosenfeld, Four Centuries of Clinical Chemistry, p. 438).