The significance of late systolic murmurs and mid-late systolic clicks.

See also J. B. Barlow, W.A. Pocock P. Marchand, M. Denny, "The significance of late systolic murmurs," Am Heart J., 66 (1963) 443- 452

Barlow revolutionized thinking about the pathophysiology of mitral regurgitation when he defined the mitral valve prolapse syndrome, which was termed Barlow's syndrome. "Barlow entered the international cardiology scene in 1963 with publication of his landmark paper on the midsystolic click and late systolic murmur, subsequently known as Barlow's syndrome. It was Barlow who demonstrated the fact that the midsystolic click(s) and late systolic murmur were in fact associated with billowing of the mitral valve leaflets and mitral regurgitation, respectively" (Profiles in Cardiology, 460-461).