RNA-programmed genome editing in human cells.

Order of authorship in the original publication: Jinek, East, Cheng...Doudna. Doudna and colleagues presented the first demonstration that the CRISPR Cas/Cas9 bacterial editing tool functions could be applied in human cells. The DNA of cells modified in this research were human embryonic kidney cells called HEK-293. The authors summarized the consequences of this paper in the last sentence of their Abstract, which read, "These results show that RNA-programmed genome editing is a facile strategy for introducing site-specific genetic changes in human cells." Digital facsimile from PubMedCentral at this link.

(Thanks to Juan Weiss for this reference and its interpretation.)