On the nature and treatment of the deformities of the human frame.

Little was the first eminent orthopedic surgeon in the British Isles. He studied under Stromeyer and, in 1838, he founded the Orthopaedic Institution, now the (Royal) National Orthopaedic Hospital, London. The above work is an elaboration of lectures delivered in 1843.

Early description of progressive muscular dystrophy (p. 14).