The Framingham Study: An epidemiological investigation of cardiovascular disease.

"The Framingham Heart Study is a long-term, ongoing cardiovascular cohort study on residents of the town of Framingham, Massachusetts. The study began in 1948 with 5,209 adult subjects from Framingham, and is now on its third generation of participants.^[1] Prior to it almost nothing was known about the "epidemiology of hypertensive or arteriosclerotic cardiovascular disease".^[2] Much of the now-common knowledge concerning heart disease, such as the effects of diet, exercise, and common medications such as aspirin, is based on this longitudinal study. It is a project of the National Heart, Lung, and Blood Institute, in collaboration with (since 1971) Boston University.^[1] "(Wikipedia article on Framingham Heart Study)

For further information regarding the Framingham Study, including the complete bibliography of publications from the study, see their website: https://www.framinghamheartstudy.org/

Digital facsimile of the 1968 paper from the Internet Archive at this link.