Drugs on trial: Experimental pharmacology and therapeutic innovation in the eighteenth century.

 "This book demonstrates that the basic methodology of the field, including chemical analysis, in vitro testing, animal experimentation and human research, was already developed in the course of the seventeenth and eighteenth centuries. Putting remedies on trial was stimulated by the challenge to Galenism through new chemical, mechanical and vitalist concepts of disease, by the import of exotic drugs and the flourishing trade with secret medicines. The book describes the main issues of eighteenth-century pharmacology and therapeutics and provides detailed case studies of three key areas: lithontriptics (remedies against urinary stones), opium, and Peruvian bark (quinine). It shows how pharmacological knowledge and therapeutic change were promoted in medical centres of the time, such as Edinburgh, London, Paris, Halle and Göttinge" (publisher).