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Garrison-Morton-Norman History of Medicine

HORVITZ, Howard Robert (1947 – )

1947 –

3 entries in the GMN corpus.

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1977 CE

#9938

Post-embryonic cell lineages of the nematode Caenorhabditis elegans.

SULSTON, Sir John Edward (1942 – 2018)
SULSTON, Sir John Edward (1942 – 2018) HORVITZ, Howard Robert (1947 – )

Complete map of the nematode's neurons. Sulston and Horvitz tracked every non-gonadal cell division that occurred during larval development, and published a complete description of these lineages in 1977.

1986 CE

#9939

Genetic control of programmed cell death in the nematode C. elegans.

HORVITZ, Howard Robert (1947 – ) ELLIS, Hilary M.

Using C. elegans to investigate whether there was a genetic program controlling cell death, or apoptosis, In 1986, Horvitz identified the first "death genes", ced-3 and ced-4. He showed that functional ced-3 and ced-4…

1991 CE

#9940

Mechanisms and functions of cell death.

HORVITZ, Howard Robert (1947 – ) ELLIS, Ronald E. YUAN, Junying (1959 – )

Horvitz and colleagues identified several key components in the molecular pathway of programmed cell death, including: EGL-1, a protein which activates apoptosis by inhibiting CED-9.